oxidative stress – World Institute of Pain

Oxidative Stress and Opioids

Březen 30, 2025 autor: Jakub Štofila

In recent years, research has shown the involvement of free radicals in the development of the pain that accompanies many pathological conditions. In the treatment of acute and chronic pain, the most effective therapies are natural and synthetic opioid alkaloids. Their metabolism in itself may contribute to the formation of free radicals and thus affect … Číst dál

Plasma antioxidant status in patients undergoing long-term opioid treatment

Březen 30, 2025Březen 30, 2025 autor: Jakub Štofila

Opioid treatment is now an integral part of pharmacotherapy for severe chronic malignant and non-malignant pain. Currently, there is a sufficient selection of opioids to allow individualized pain treatment. Several experimental studies have confirmed the effect of opioids on oxidative stress. The aim of this work is to determine the presence of redox changes occurring … Číst dál